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Martinez-Outschoorn, U.E., Pavlides, S., Howell, A., Pestell, R.G., Tanowitz, H.B., Sotgia, F., Lisanti, M.P. (2011).
Stromal-Epithelial Metabolic Coupling in Cancer: Integrating Autophagy and Metabolism in the Tumor Microenvironment.
Int J Biochem Cell Biol. February 5, In Press.
Pavlides, S., Gutierrez-Pajares, L.J., Danilo, C., Lisanti, M.P., Frank. P.G. (2011).
Atherosclerosis, Caveolae, and Caveolin-1.
Publishers Landes Biosciences. From the book Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms
Casey, T., Sotgia, F., Whitaker-Menezes, D., Balliet, R., Eaton, G., Martinez-Outschoorn, U.E., Pavlides, S., Howell, A., Iozzo, R., Pestell, R.G., Scherer, P.E., Capozza, F., and M.P. Lisanti. (2011).
Caveolin-1 and Mitochondrial SOD2 (MnSOD) Function as Tumor Suppressors in the Stromal Microenvironment: A New Genetically Tractable Model for Human Cancer Associated Fibroblasts.
Cancer Biology and Therapy, 11 (4):383-394.
Martinez-Outschoorn, U.E., Trimmer, C., Lin, Z., Whitaker-Menezes , D., Chiavarina, B., Zhou, J., Wang, C., Pavlides, S., Martinez-Cantarin, M.P., Capozza, F., Witkiewicz, A.K., Flomenberg, N., Howell, A., Pestell, R.G., Caro, J., Lisanti, M.P., and Sotgia, F. (2010).
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
Cell Cycle, 9 (17):3515-3533.
Chiavarina, B., Whitaker-Menezes, D., Migneco, G., Martinez-Outschoorn, U.E., Pavlides, S., Howell, A., Tanowitz, H.B., Casimiro, M.C., Wang, C., Pestell, R.G., Grieshaber, P., Caro, J., Sotgia, F., and Lisanti, M.P. (2010).
HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.
Cell Cycle, 9 (17):3534-3551.
Bonuccelli, G., Tsirigos, A., Whitaker-Menezes, D., Pavlides, S., Pestell, R.G., Chiavarina, B., Frank, P.G., Flomenberg, N., Howell, A., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti., M.P. (2010).
Ketones and lactate “fuel” tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
Cell Cycle, 9 (17):3506-3514.
Lisanti, M.P., Martinez-Outschoorn, U.E., Chiavarina, B., Pavlides, S., Whitaker-Menezes, D., Tsirigos, A., Witkiewicz, A.K., Lin, Z., Balliet, R., Howell, A., and Sotgia, F.. (2010).
Understanding the “Lethal” Drivers of Tumor-Stroma Co-Evolution: Emerging Role(s) for Hypoxia, Oxidative Stress, and Autophagy/Mitophagy in the Tumor Micro-Environment.
Cancer Biology & Therapy, 15: 10 (6):537-542.
Pavlides, S., Tsirigos, A., Migneco, G., Whitaker-Menezes, D., Chiavarina, B., Flomenberg, N., Frank, P.G., Casimiro, M.C., Wang, C., Pestell, R.G., Martinez-Outschoorn, U.E., Howell, A., Sotgia, F., and Lisanti., M.P. (2010).
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
Cell Cycle, 9 (17):3485-3505.
Martinez-Outschoorn, U.E., Balliet, R., Rivadeneira, D., Chiavarina, B., Pavlides, S., Wang, C., Whitaker-Menezes, D., Daumer, K.M., Lin, Z., Witkiewicz, A.K., Flomenberg, N., Howell, A., Pestell, R.G., Knudsen, E., Sotgia, F. and Lisanti, M.P. (2010).
Oxidative stress in cancer fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Cell Cycle, 9 (16):3256-3276.
Martinez-Outschoorn, U.E., Pavlides, S., Whitaker-Menezes, D., Daumer, K.M., Milliman, J.N., Chiavarina, B., Migneco, G., Witkiewicz, A.K., Martinez-Cantarin, M.P., Flomenberg, N., Howell, A., Pestell, R.G., Lisanti, M.P. and Sotgia, F. (2010).
Tumor Cells Induce the Cancer Associated Fibroblast Phenotype Via Caveolin-1 Degradation: Implications for Breast Cancer and DCIS Therapy with Chloroquine.
Cell Cycle, 9 (12):2423-2433.
Migneco, G., Whitaker-Menezes, D., Chiavarina, B., Castello-Cros, R., Pavlides, S., Pestell, R.G., Fatatis, A., Flomenberg, N., Tsirigos, A., Martinez-Outschoorn, U.E., Howell, A., Sotgia, F. and Lisanti, M.P. (2010).
Glycolytic Cancer Associated Fibroblasts Promote Breast Cancer Tumor Growth, without a Measurable Increase in Angiogenesis: Evidence for Stromal-Epithelial Metabolic Coupling.
Cell Cycle, 9 (12):2412-2422.
Pavlides, S., Tsirigos, A., Vera, I., Flomenberg, N., Frank, P.G., Casimiro, M.C., Wang, C., Fortina, P., Addya, S., Pestell, R.G., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti., M.P. (2010).
Loss of Stromal Caveolin-1 Leads to Oxidative Stress, Mimics Hypoxia, and Drives Inflammation in the Tumor Microenvironment, Conferring the “Reverse Warburg Effect”. A Transcriptional Informatics Analysis with Validation”.
Cell Cycle, 9 (11):2201-2219.
Bonuccelli, G., Whitaker-Menezes, D., Castello-Cros, R., Pavlides, S., Pestell, R.G., Fatatis, A., Witkiewicz, A.K., Vander Heiden, M.G., Migneco, G., Chiavarina, B., Frank, P.G., Capozza, F., Flomenberg, N., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti., M.P. (2010).
The Reverse Warburg Effect: Glycolysis Inhibitors Prevent the Tumor Promoting Effects of Caveolin-1 Deficient Cancer Associated Fibroblasts”.
Cell Cycle, 9 (10):1960-1971.
Pavlides, S., Tsirigos, A., Vera, I., Flomenberg, N., Frank, P.G., Pestell, R.G., Martinez-Outschoorn, U.E., Howell, A., Sotgia, F., and Lisanti, M.P. (2010).
Transcriptional Evidence for the “Reverse Warburg Effect” in Human Breast Cancer Stroma: Similarities with Alzheimer’s Disease Brain.
Aging, 2 (4):185-199.
Martinez-Outschoorn, U.E., Whitaker-Menezes , D., Pavlides, S., Chiavarina, B., Bonuccelli, G., Trimmer, C., Tsirigos, A. Migneco, G., Witkiewicz, A.K., Balliet, R., Mercier, I., Wang, C., Flomenberg, N., Howell, A., Lin, Z., Caro, J., Pestell, R.G., Sotgia, F. and Lisanti, M.P. (2010).
The “Autophagic Tumor Stroma Model of Cancer Cell Metabolism” or “Battery-Operated Tumor Growth”: A Simple Solution to the Autophagy Paradox..
Cell Cycle, 1: 9 (21).
Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A.K., Frank, P.G., Casimiro, M.C., Wang, C., Fortina, P., Addya, S., Pestell, R.G., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti, M.P. (2009).
The Reverse Warburg Effect: Aerobic Glycolysis in Cancer Associated Fibroblasts and the Tumor Stroma.
Cell Cycle, 8: (23) 3984-4001.
Frank, P.G., Pavlides, S., and M.P. Lisanti. (2009).
Caveolae and Transcytosis in Endothelial Cells: Role in Atherosclerosis.
Cell Tissue Res. 335: 41-7.
Mercier, I., Jasmin, J-F., Pavlides, S., Minetti, C., Pestell, R.G., Frank, P.G., Sotgia, F., and M.P. Lisanti. (2009).
Clinical and Translational Implications of the Caveolin Gene Family: Lessons from Mouse Models and Human Genetic Disorders.
Lab Invest, 89:614-23.
Frank, P.G., Pavlides, S., Cheung, W.C., Daumer, K., and M.P. Lisanti. (2008).
Role of Caveolin-1 in the Regulation of Lipoprotein Metabolism.
Am. J. Physiol. (Cell Physiol.), 295: C242-8.
Frank, P.G., Cheung, M.W., Pavlides, S., Llavaverias, G., Park, D.S., and M.P. Lisanti. 2006.
Caveolin-1 and Regulation of Cellular Cholesterol Homeostasis.
Am J Physiol (Heart Circ Physiol.), 291: H677-86.-1747.
Teupser. D., Pavlides, S., Tan M, Gutierrez-Ramos JC, Kolbeck R, Breslow JL. (2004)
The major reduction of atherosclerosis in fractalkine (CX3CLI deficient mice is at the brachiocephalic artery not the aortic root.
Proc Natl Acad Sci 101(51):17795-800.
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